A recombinant Solution
The Best of both worlds
Clinical applications and research development in tissue engineering and regenerative medicine inevitably require bio-compatible materials. These materials come in two classic flavors —(1) synthetic polymers and (2) decellularized tissue— each with its own advantages and disadvantages.
At inSoma Bio, we develop recombinant, protein-based materials that merge these advantages into a single technology. By genetically engineering protein-based materials to mimic naturally found elastin —a core component of the extracellular environment— we can create bio-compatible materials with a level of precision superior even to synthetic polymers.
Porous and mechanically supportive
Capable of remodeling
Molecular level control
Easy scale-up and manufacturing
A Response to Body Heat
Our core protein biomatrices, which we call Fractomers, are composed of a simple modular design. Each protein contains carefully controlled ratios of structured physical cross-linking domains, bio-active sequences (when desired), and unstructured regions which control their thermo-responsiveness. This design translates into a system which forms fractal-like porous networks with excellent material properties only after injection and exposure to body heat. As a result, these materials can be handled as simple, low-viscosity fluids, easily adaptable to current state-of-the-art procedures.
For more information, see our recent Media Highlight.